TFE3 Produkte
(Transcription Factor E3 (TFE3))
Kategorien
The microphthalmia transcription factor/transcription factor E (MITF-TFE) family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors includes four family members: MITF, TFE3, TFEB and TFEC. The TEF3 protein encoded by this gene activates transcription through binding to the muE3 motif of the immunoglobulin heavy-chain enhancer. The TFEC protein forms heterodimers with the TEF3 protein and inhibits TFE3-dependent transcription activation. The TEF3 protein interacts with transcription regulators such as E2F3, SMAD3, and LEF-1, and is involved in TGF-beta-induced transcription, playing important roles in cell growth, proliferation, and osteoclast and macrophage differentiation. The TFE3 protein also activates hepatic IRS-2 gene, and induces hexokinase II (HK2) and insulin-induced gene 1 (INSIG1)\; it participates in insulin signaling and could be a therapeutic target for diabetes. This gene is also involved in chromosomal translocations, resulting in different fusion gene products in papillary renal cell carcinomas and alveolar soft part sarcomas, such as PRCC-TFE3, RCC17-TFE3, PSF-TFE3, NonO (p54nrb)-TFE3 and ASPL-TFE3.[provided by RefSeq, Dec 2009].
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Ausgewählte TFE3 Kategorien
TFE3 Antikörper
High quality antibodies with extensive validation data.
TFE3 ELISA Kits
Reliable ELISA kits for a wide range of species.
TFE3 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene TFE3 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Mouse
Applikation
WB, IF
Validierungen
- (4)
Kat. Nr.
ABIN1538859
Menge
400 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse
Applikation
WB, ELISA, IHC, IF, ICC
Validierungen
- (3)
Kat. Nr.
ABIN6257542
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IHC
Validierungen
- (3)
Kat. Nr.
ABIN1683323
Menge
100 μg
Datenblatt
Datenblatt
Empfohlene TFE3 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6960060
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human, Mouse
Analytical Method
Qualitative DNA-Binding ELISA
Validierungen
Kat. Nr.
ABIN5648528
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN5659395
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene TFE3 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7125447
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1322559
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1322561
Menge
10 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren TFE3 Produkten
: "Hypoxia induces TFE3 expression in head and neck squamous cell carcinoma." in: Oncotarget, Vol. 7, Issue 10, pp. 11651-63, (2016) (PubMed).: "Resetting transcription factor control circuitry toward ground-state pluripotency in human." in: Cell, Vol. 158, Issue 6, pp. 1254-69, (2014) (PubMed).
: "Exit from pluripotency is gated by intracellular redistribution of the bHLH transcription factor Tfe3." in: Cell, Vol. 153, Issue 2, pp. 335-47, (2013) (PubMed).
: "Derivation of novel human ground state naive pluripotent stem cells. ..." in: Nature, Vol. 504, Issue 7479, pp. 282-6, (2013) (PubMed).
: "Inactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localization." in: PLoS ONE, Vol. 5, Issue 12, pp. e15793, (2011) (PubMed).
: "Myc/Max and other helix-loop-helix/leucine zipper proteins bend DNA toward the minor groove." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 24, pp. 11779-83, (1993) (PubMed).
: "TFEC, a basic helix-loop-helix protein, forms heterodimers with TFE3 and inhibits TFE3-dependent transcription activation." in: Molecular and cellular biology, Vol. 13, Issue 8, pp. 4505-12, (1993) (PubMed).
: "TFE3: a helix-loop-helix protein that activates transcription through the immunoglobulin enhancer muE3 motif." in: Genes & development, Vol. 4, Issue 2, pp. 167-79, (1990) (PubMed).
: "A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins." in: Cell, Vol. 56, Issue 5, pp. 777-83, (1989) (PubMed).
Synonyme und alternative Namen zu TFE3
transcription factor binding to IGHM enhancer 3 (TFE3), transcription factor E3 (Tfe3), transcription factor binding to IGHM enhancer 3 (Tfe3), transcription factor binding to IGHM enhancer 3 S homeolog (tfe3.S), transcription factor binding to IGHM enhancer 3a (tfe3a), bHLHe33, cb873, F830016E06Rik, RCCP2, RCCX1, RGD1559642, Tcfe3, Tfe-3, TFEA, zgc:109815Bezeichner auf Proteinebene für TFE3
- class E basic helix-loop-helix protein 33
- transcription factor E family, member A
- transcription factor E3
- transcription factor for IgH enhancer
- transcription factor for immunoglobulin heavy-chain enhancer 3
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