Topoisomerase II alpha Produkte
(Topoisomerase (DNA) II alpha 170kDa (TOP2A))
Kategorien
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010].
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Ausgewählte Topoisomerase II alpha Kategorien
Topoisomerase II alpha Antikörper
High quality antibodies with extensive validation data.
Topoisomerase II alpha ELISA Kits
Reliable ELISA kits for a wide range of species.
Topoisomerase II alpha Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene Topoisomerase II alpha Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Mouse, Rat
Applikation
IHC, IF
Validierungen
- (12)
Kat. Nr.
ABIN7075937
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IF, IHC (p)
Validierungen
- (1)
- (5)
Kat. Nr.
ABIN563224
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, FACS, ICC
Validierungen
- (7)
Kat. Nr.
ABIN7193564
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene Topoisomerase II alpha ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6970754
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Qualitative Cell ELISA
Validierungen
Kat. Nr.
ABIN1380476
Menge
2 x 96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Qualitative Cell ELISA
Validierungen
Kat. Nr.
ABIN1380808
Menge
2 x 96 tests
Datenblatt
Datenblatt
Empfohlene Topoisomerase II alpha Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1323347
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7013599
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN2751809
Menge
5 applications
Datenblatt
Datenblatt
Neueste Publikationen zu unseren Topoisomerase II alpha Produkten
: "Type IIB DNA topoisomerase is downregulated by trastuzumab and doxorubicin to synergize cardiotoxicity." in: Oncotarget, Vol. 9, Issue 5, pp. 6095-6108, (2018) (PubMed).: "Chromosome Scaffold is a Double-Stranded Assembly of Scaffold Proteins." in: Scientific reports, Vol. 5, pp. 11916, (2015) (PubMed).
: "Tumour expression of bladder cancer-associated urinary proteins." in: BJU international, Vol. 112, Issue 3, pp. 407-15, (2013) (PubMed).
: "Antibodies biotinylated using a synthetic Z-domain from protein A provide stringent in situ protein detection." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 61, Issue 11, pp. 773-84, (2013) (PubMed).
: "DNA topoisomerase IIalpha is required for RNA polymerase II transcription on chromatin templates." in: Nature, Vol. 413, Issue 6854, pp. 435-8, (2001) (PubMed).
Synonyme und alternative Namen zu Topoisomerase II alpha
DNA topoisomerase II alpha (TOP2A), DNA topoisomerase II, alpha isozyme (Bm1_08705), topoisomerase (DNA) II alpha (Top2a), DNA topoisomerase II alpha (Top2a), topoisomerase (DNA) II alpha (TOP2A), Zincin-like metalloproteases family protein (AT5G10540), DNA topoisomerase II alpha (top2a), F12B17.110, F12B17_110, fc08c07, thimet metalloendopeptidase 2, Top-2, TOP-2, TOP2, TOP2A, TP2A, wu:fc08c07Bezeichner auf Proteinebene für Topoisomerase II alpha
- DNA gyrase
- DNA topoisomerase (ATP-hydrolyzing)
- DNA topoisomerase 2-alpha
- DNA topoisomerase II, 170 kD
- DNA topoisomerase II, alpha isozyme
- DNA Topoisomerase II alpha
- topoisomerase (DNA) 2 alpha
- DNA topoisomeraseII_alpha
- topoisomerase (DNA) II alpha
- Thimet metalloendopeptidase 2
- Zincin-like metalloproteases family protein 2
- topoisomerase 2
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