TPMT Produkte
(Thiopurine S-Methyltransferase (TPMT))
Kategorien
This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q. [provided by RefSeq, Jul 2008].
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Ausgewählte TPMT Kategorien
TPMT Antikörper
High quality antibodies with extensive validation data.
TPMT ELISA Kits
Reliable ELISA kits for a wide range of species.
TPMT Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene TPMT Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, IP, ICC
Validierungen
- (7)
Kat. Nr.
ABIN7435148
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IF, IHC (p)
Validierungen
- (2)
- (5)
Kat. Nr.
ABIN563239
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Dog, Human
Applikation
WB, IHC, IHC (p), FACS
Validierungen
- (6)
Kat. Nr.
ABIN1501480
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene TPMT ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6970609
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6962695
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6959901
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene TPMT Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1323441
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN934951
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7396802
Menge
100 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren TPMT Produkten
: "Sorting nexin 27 interacts with multidrug resistance-associated protein 4 (MRP4) and mediates internalization of MRP4." in: The Journal of biological chemistry, Vol. 287, Issue 18, pp. 15054-65, (2012) (PubMed).: "S-adenosylmethionine regulates thiopurine methyltransferase activity and decreases 6-mercaptopurine cytotoxicity in MOLT lymphoblasts." in: Biochemical pharmacology, Vol. 77, Issue 12, pp. 1845-53, (2009) (PubMed).
: "A novel gene delivery system for stable transfection of thiopurine-S-methyltransferase gene in versatile cell types." in: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V, Vol. 69, Issue 1, pp. 23-30, (2008) (PubMed).
: "Human thiopurine S-methyltransferase pharmacogenetics: variant allozyme misfolding and aggresome formation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 26, pp. 9394-9, (2005) (PubMed).
: "Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein." in: Nature, Vol. 375, Issue 6533, pp. 691-4, (1995) (PubMed).
Synonyme und alternative Namen zu TPMT
thiopurine S-methyltransferase L homeolog (tpmt.L), thiopurine S-methyltransferase, tandem duplicate 2 (tpmt.2), thiopurine S-methyltransferase TpmT (tpmT), thiopurine S-methyltransferase (MCA0794), thiopurine S-methyltransferase (Pnap_4948), thiopurine S-methyltransferase (Hhal_1383), thiopurine S-methyltransferase (TK90_1044), thiopurine S-methyltransferase (Slit_1144), thiopurine S-methyltransferase (Tint_0842), Thiopurine S-methyltransferase (Fbal_3334), thiopurine S-methyltransferase (Celly_3188), thiopurine S-methyltransferase (Weevi_1737), Thiopurine S-methyltransferase (Psefu_2696), Thiopurine S-methyltransferase (Metme_3860), thiopurine methyltransferase (Tpmt), thiopurine S-methyltransferase (TPMT), thiopurine S-methyltransferase (Tpmt), AW106912, MGC84277, NHLRC1Bezeichner auf Proteinebene für TPMT
- thiopurine S-methyltransferase
- Thiopurine S-methyltransferase
- S-adenosyl-L-methionine:thiopurine S-methyltransferase
- thiopurine methyltransferase
- NHL repeat containing 1
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