TRPM8 Produkte
(Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8))
Kategorien
Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.
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Ausgewählte TRPM8 Kategorien
TRPM8 Antikörper
High quality antibodies with extensive validation data.
TRPM8 ELISA Kits
Reliable ELISA kits for a wide range of species.
TRPM8 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene TRPM8 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IHC (p)
Validierungen
- (5)
Kat. Nr.
ABIN392821
Menge
400 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC
Validierungen
- (5)
Kat. Nr.
ABIN3029240
Menge
0.4 mL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC, IF
Validierungen
- (5)
Kat. Nr.
ABIN3029242
Menge
0.4 mL
Datenblatt
Datenblatt
Empfohlene TRPM8 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6960128
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN5659487
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene TRPM8 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7413904
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr.
ABIN3116017
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr.
ABIN3136669
Menge
1 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren TRPM8 Produkten
: "TRPM8 thermosensation in poikilotherms mediates both skin colour and locomotor performance responses to cold temperature." in: Communications biology, Vol. 6, Issue 1, pp. 127, (2023) (PubMed).: "TRPM8-Rap1A Interaction Sites as Critical Determinants for Adhesion and Migration of Prostate and Other Epithelial Cancer Cells." in: Cancers, Vol. 14, Issue 9, (2022) (PubMed).
: "Gpr83 Tunes Nociceptor Function, Controlling Pain." in: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, (2022) (PubMed).
: "TRPM8 as an Anti-Tumoral Target in Prostate Cancer Growth and Metastasis Dissemination." in: International journal of molecular sciences, Vol. 23, Issue 12, (2022) (PubMed).
: "Testosterone-androgen receptor: The steroid link inhibiting TRPM8-mediated cold sensitivity." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 34, Issue 6, pp. 7483-7499, (2021) (PubMed).
: "TRPM8-androgen receptor association within lipid rafts promotes prostate cancer cell migration." in: Cell death & disease, Vol. 10, Issue 9, pp. 652, (2020) (PubMed).
: "Activation of Transient Receptor Potential Melastatin Subtype 8 Attenuates Cold-Induced Hypertension Through Ameliorating Vascular Mitochondrial Dysfunction." in: Journal of the American Heart Association, Vol. 6, Issue 8, (2018) (PubMed).
: "TRPM8 in the negative regulation of TNFα expression during cold stress." in: Scientific reports, Vol. 7, pp. 45155, (2017) (PubMed).
: "TRPM8 inhibits endothelial cell migration via a non-channel function by trapping the small GTPase Rap1." in: The Journal of cell biology, Vol. 216, Issue 7, pp. 2107-2130, (2017) (PubMed).
: "Antibodies to the extracellular pore loop of TRPM8 act as antagonists of channel activation." in: PLoS ONE, Vol. 9, Issue 9, pp. e107151, (2015) (PubMed).
Synonyme und alternative Namen zu TRPM8
transient receptor potential cation channel subfamily M member 8 (TRPM8), transient receptor potential cation channel subfamily M member 8b L homeolog (trpm8b.L), transient receptor potential cation channel subfamily M member 8 (Trpm8), transient receptor potential cation channel, subfamily M, member 8 (Trpm8), transient receptor potential cation channel, subfamily M, member 8 (TRPM8), CMR1, LTrpC-6, ltrpc6, LTRPC6, Trp-p8, TRPM8, trpm8b, trpp8, TRPP8Bezeichner auf Proteinebene für TRPM8
- transient receptor potential cation channel, subfamily M, member 8
- transient receptor potential cation channel subfamily M member 8b
- transient receptor potential cation channel subfamily M member 8
- transient potential cation channel subfamily M member 8
- LTrpC-6
- long transient receptor potential channel 6
- short form of the TRPM8 cationic channel
- transient receptor potential p8
- transient receptor potential subfamily M member 8
- trp-p8
- TRP ion channel TRPM8
- transient receptor potential-p8
- cold menthol receptor 1
- cold/menthol receptor 1
- menthol receptor
- transient receptor potential M8 protein
- transient receptor potential cation channel, subfamily M, member 8 (predicted), 3 prime
- transient receptor potential cation channel, subfamily M, member 8 (predicted), 5 prime
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