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TXK Produkte

(TXK tyrosine Kinase (TXK))
Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T- cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskekleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. With PARP1 and EEF1A1, TXK forms a complex that acts as a T-helper 1 (Th1) cell- specific transcription factor and binds the promoter of IFNG to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr- 201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor.

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Ausgewählte TXK Kategorien

TXK Antikörper

High quality antibodies with extensive validation data.

TXK ELISA Kits

Reliable ELISA kits for a wide range of species.

TXK Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene TXK Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation ELISA, WB, IHC, IF
Validierungen
  • (4)
Kat. Nr. ABIN7174076
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, IHC (p)
Validierungen
  • (3)
Kat. Nr. ABIN392114
Menge 400 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation ELISA, WB, IF
Validierungen
  • (3)
Kat. Nr. ABIN521176
Menge 100 μg
Datenblatt Datenblatt

Empfohlene TXK ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6971009
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Semi-Quantitative Sandwich ELISA
Validierungen
Kat. Nr. ABIN4886333
Menge 96 tests
Datenblatt Datenblatt

Empfohlene TXK Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1324214
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Rat
Source Insect Cells
Validierungen
Kat. Nr. ABIN5509229
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Insect Cells
Validierungen
Kat. Nr. ABIN5509188
Menge 10 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren TXK Produkten

Suzuki, Nara, Suzuki: "Skewed Th1 responses caused by excessive expression of Txk, a member of the Tec family of tyrosine kinases, in patients with Behcet's disease." in: Clinical medicine & research, Vol. 4, Issue 2, pp. 147-51, (2006) (PubMed).

Takeba, Nagafuchi, Takeno, Kashiwakura, Suzuki: "Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 168, Issue 5, pp. 2365-70, (2002) (PubMed).

Synonyme und alternative Namen zu TXK

TXK tyrosine kinase (TXK), TXK tyrosine kinase (Txk), tyrosine-protein kinase TXK (LOC100544958), A130089B16Rik, BTKL, Btkl, PSCTK5, PTK4, RLK, Rlk, TKL

Bezeichner auf Proteinebene für TXK

  • PTK4 protein tyrosine kinase 4
  • protein-tyrosine kinase 4
  • resting lymphocyte kinase
  • tyrosine kinase
  • tyrosine-protein kinase TXK
  • PTK-RL-18
  • TXK tyrosine kinase
  • tyrosine-protein kinase TXK-like
  • LOW QUALITY PROTEIN: tyrosine-protein kinase TXK
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