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TYK2 Produkte

(Tyrosine Kinase 2 (TYK2))

Kategorien

This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008].

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Ausgewählte TYK2 Kategorien

TYK2 Antikörper

High quality antibodies with extensive validation data.

TYK2 ELISA Kits

Reliable ELISA kits for a wide range of species.

TYK2 Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene TYK2 Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation WB, ELISA, IF, IHC (p), IP
Validierungen
  • (7)
Kat. Nr. ABIN563303
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, ELISA, IHC (p)
Validierungen
  • (6)
Kat. Nr. ABIN521186
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, IHC, IF
Validierungen
  • (6)
Kat. Nr. ABIN3022988
Menge 100 μL
Datenblatt Datenblatt

Empfohlene TYK2 ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Semi-Quantitative Sandwich ELISA
Validierungen
  • (3)
Kat. Nr. ABIN1981732
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6971021
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6960329
Menge 96 tests
Datenblatt Datenblatt

Empfohlene TYK2 Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1324253
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Insect Cells
Validierungen
Kat. Nr. ABIN5509189
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Escherichia coli (E. coli)
Validierungen
Kat. Nr. ABIN7394390
Menge 100 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren TYK2 Produkten

Forsström, Axnäs, Stengele, Bühler, Albert, Richmond, Hu, Nilsson, Hudson, Rockberg, Uhlen: "Proteome-wide epitope mapping of antibodies using ultra-dense peptide arrays." in: Molecular & cellular proteomics : MCP, Vol. 13, Issue 6, pp. 1585-97, (2014) (PubMed).

Sanda, Tyner, Gutierrez, Ngo, Glover, Chang, Yost, Ma, Fleischman, Zhou, Yang, Kleppe, Ahn, Tatarek, Kelliher, Neuberg, Levine, Moriggl, Müller, Gray, Jamieson, Weng, Staudt, Druker, Look: "TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia." in: Cancer discovery, Vol. 3, Issue 5, pp. 564-77, (2013) (PubMed).

Shaw, Freeman, Scott, Fox, Bzik, Belkaid, Yap: "Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 12, pp. 7263-71, (2006) (PubMed).

Zheng, Hu, Quinn, Wang: "Phosphotyrosine proteomic study of interferon alpha signaling pathway using a combination of immunoprecipitation and immobilized metal affinity chromatography." in: Molecular & cellular proteomics : MCP, Vol. 4, Issue 6, pp. 721-30, (2005) (PubMed).

Stoiber, Kovacic, Schuster, Schellack, Karaghiosoff, Kreibich, Weisz, Artwohl, Kleine, Muller, Baumgartner-Parzer, Ghysdael, Freissmuth, Sexl: "TYK2 is a key regulator of the surveillance of B lymphoid tumors." in: The Journal of clinical investigation, Vol. 114, Issue 11, pp. 1650-8, (2004) (PubMed).

Seto, Nakajima, Suto, Shimoda, Saito, Nakayama, Iwamoto: "Enhanced Th2 cell-mediated allergic inflammation in Tyk2-deficient mice." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 2, pp. 1077-83, (2003) (PubMed).

Ragimbeau, Dondi, Alcover, Eid, Uzé, Pellegrini: "The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression." in: The EMBO journal, Vol. 22, Issue 3, pp. 537-47, (2003) (PubMed).

Kiian, Tkachuk, Haller, Dumler: "Urokinase-induced migration of human vascular smooth muscle cells requires coupling of the small GTPases RhoA and Rac1 to the Tyk2/PI3-K signalling pathway." in: Thrombosis and haemostasis, Vol. 89, Issue 5, pp. 904-14, (2003) (PubMed).

Lukashova, Chen, Duhé, Rola-Pleszczynski, Stanková: "Janus kinase 2 activation by the platelet-activating factor receptor (PAFR): roles of Tyk2 and PAFR C terminus." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 171, Issue 7, pp. 3794-800, (2003) (PubMed).

Blesofsky, Mowen, Arduini, Baker, Murphy, Bowtell, David: "Regulation of STAT protein synthesis by c-Cbl." in: Oncogene, Vol. 20, Issue 50, pp. 7326-33, (2001) (PubMed).

Synonyme und alternative Namen zu TYK2

tyrosine kinase 2 (TYK2), tyrosine kinase 2 (Tyk2), JTK1

Bezeichner auf Proteinebene für TYK2

  • non-receptor tyrosine-protein kinase TYK2
  • tyrosine kinase TYK2
  • non-receptor tyrosine kinase Tyk2
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