TYMS Produkte
(Thymidylate Synthetase (TYMS))
Kategorien
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq, Jul 2008].
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Ausgewählte TYMS Kategorien
TYMS Antikörper
High quality antibodies with extensive validation data.
TYMS ELISA Kits
Reliable ELISA kits for a wide range of species.
TYMS Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene TYMS Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, IP, ICC
Validierungen
- (8)
Kat. Nr.
ABIN7436399
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IF, ELISA, IHC (p)
Validierungen
- (6)
Kat. Nr.
ABIN563306
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IF, IHC (p), IP, ICC
Validierungen
- (8)
Kat. Nr.
ABIN2855587
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene TYMS ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6959948
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Validierungen
Kat. Nr.
ABIN1161751
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Rat
Analytical Method
Validierungen
Kat. Nr.
ABIN1161752
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene TYMS Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN666924
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1324259
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1324257
Menge
10 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren TYMS Produkten
: "Raltitrexed Inhibits HepG2 Cell Proliferation via G0/G1 Cell Cycle Arrest." in: Oncology research, Vol. 23, Issue 5, pp. 237-48, (2016) (PubMed).: "Mass spectrometric/bioinformatic identification of a protein subset that characterizes the cellular activity of anticancer peptides." in: Journal of proteome research, Vol. 13, Issue 11, pp. 5250-61, (2014) (PubMed).
: "Thymidylate synthase as a prognostic biomarker for locally advanced rectal cancer after multimodal treatment." in: Annals of surgical oncology, Vol. 18, Issue 9, pp. 2442-52, (2012) (PubMed).
: "DNA methylation-regulated miR-193a-3p dictates resistance of hepatocellular carcinoma to 5-fluorouracil via repression of SRSF2 expression." in: The Journal of biological chemistry, Vol. 287, Issue 8, pp. 5639-49, (2012) (PubMed).
: "Comparative analysis of thymidylate synthase at the protein, mRNA, and DNA levels as prognostic markers in colorectal adenocarcinoma." in: Journal of surgical oncology, Vol. 100, Issue 7, pp. 546-52, (2009) (PubMed).
: "Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate." in: Journal of the National Cancer Institute, Vol. 96, Issue 2, pp. 134-44, (2004) (PubMed).
: "Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines." in: Molecular cancer therapeutics, Vol. 2, Issue 2, pp. 151-63, (2003) (PubMed).
: "Characterization of a polyclonal antibody to human thymidylate synthase suitable for the study of colorectal cancer specimens." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 47, Issue 12, pp. 1563-74, (1999) (PubMed).
: "Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site." in: Biochemistry, Vol. 34, Issue 50, pp. 16279-87, (1996) (PubMed).
Synonyme und alternative Namen zu TYMS
thymidylate synthetase (TYMS), thymidylate synthetase (thyA), contains intron in T4 phage (td), thymidylate synthetase (td), ThyE (thyE), thymidylate synthase (DDA3937_RS04960), thymidylate synthetase L homeolog (tyms.L), thymidylate synthase (XBJ1_RS15770), thymidylate synthase (EAMY_RS20680), thymidylate synthase (Tyms), thymidylate synthetase (Tyms), ECK2823, FN1, HST422, JW2795, TMS, ts, Ts, TSBezeichner auf Proteinebene für TYMS
- fibronectin 1
- thymidylate synthase
- thymidylate synthetase
- thymidylate synthase-like
- Tsase
- TSase
- TS
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