Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

TYMS Produkte

(Thymidylate Synthetase (TYMS))

Kategorien

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq, Jul 2008].

antibodies-online.com steht für hochwertige Forschungsprodukte. Suchen, finden und bestellen Sie Tools mit umfangreichen Validierungsdaten, Bildern, Referenzen. Unser wissenschaftlicher Kundenservice steht Ihnen jederzeit zur Verfügung, wenn Sie Fragen zur Auswahl oder Anwendung unserer Produkte haben.

Ausgewählte TYMS Kategorien

TYMS Antikörper

High quality antibodies with extensive validation data.

TYMS ELISA Kits

Reliable ELISA kits for a wide range of species.

TYMS Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene TYMS Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation WB, IHC, IP, ICC
Validierungen
  • (8)
Kat. Nr. ABIN7436399
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, IF, ELISA, IHC (p)
Validierungen
  • (6)
Kat. Nr. ABIN563306
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, IF, IHC (p), IP, ICC
Validierungen
  • (8)
Kat. Nr. ABIN2855587
Menge 100 μL
Datenblatt Datenblatt

Empfohlene TYMS ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6959948
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Mouse
Analytical Method
Validierungen
Kat. Nr. ABIN1161751
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Rat
Analytical Method
Validierungen
Kat. Nr. ABIN1161752
Menge 96 tests
Datenblatt Datenblatt

Empfohlene TYMS Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Escherichia coli (E. coli)
Validierungen
  • (1)
Kat. Nr. ABIN666924
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1324259
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1324257
Menge 10 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren TYMS Produkten

Zhao, Zhang, Sun, Zhan, Zhao: "Raltitrexed Inhibits HepG2 Cell Proliferation via G0/G1 Cell Cycle Arrest." in: Oncology research, Vol. 23, Issue 5, pp. 237-48, (2016) (PubMed).

Genovese, Gualandi, Taddia, Marverti, Pirondi, Marraccini, Perco, Pelà, Guerrini, Amoroso, Esposito, Martello, Ponterini, DArca, Costi: "Mass spectrometric/bioinformatic identification of a protein subset that characterizes the cellular activity of anticancer peptides." in: Journal of proteome research, Vol. 13, Issue 11, pp. 5250-61, (2014) (PubMed).

Conradi, Bleckmann, Schirmer, Sprenger, Jo, Homayounfar, Wolff, Rothe, Middel, Becker, Ghadimi, Beissbarth, Liersch: "Thymidylate synthase as a prognostic biomarker for locally advanced rectal cancer after multimodal treatment." in: Annals of surgical oncology, Vol. 18, Issue 9, pp. 2442-52, (2012) (PubMed).

Ma, He, Zhang, Fei, Niu, Wang, Ding, Xu, Chen, Zhu: "DNA methylation-regulated miR-193a-3p dictates resistance of hepatocellular carcinoma to 5-fluorouracil via repression of SRSF2 expression." in: The Journal of biological chemistry, Vol. 287, Issue 8, pp. 5639-49, (2012) (PubMed).

Ren, Kim, Koh, Chang, Eom, Yi, Seong, Kim, Bronner, Cho: "Comparative analysis of thymidylate synthase at the protein, mRNA, and DNA levels as prognostic markers in colorectal adenocarcinoma." in: Journal of surgical oncology, Vol. 100, Issue 7, pp. 546-52, (2009) (PubMed).

Sohn, Croxford, Yates, Lucock, Kim: "Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate." in: Journal of the National Cancer Institute, Vol. 96, Issue 2, pp. 134-44, (2004) (PubMed).

Glaser, Staver, Waring, Stender, Ulrich, Davidsen: "Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines." in: Molecular cancer therapeutics, Vol. 2, Issue 2, pp. 151-63, (2003) (PubMed).

Haqqani, Cowling, Maroun, Birnboim: "Characterization of a polyclonal antibody to human thymidylate synthase suitable for the study of colorectal cancer specimens." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 47, Issue 12, pp. 1563-74, (1999) (PubMed).

Schiffer, Clifton, Davisson, Santi, Stroud: "Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site." in: Biochemistry, Vol. 34, Issue 50, pp. 16279-87, (1996) (PubMed).

Synonyme und alternative Namen zu TYMS

thymidylate synthetase (TYMS), thymidylate synthetase (thyA), contains intron in T4 phage (td), thymidylate synthetase (td), ThyE (thyE), thymidylate synthase (DDA3937_RS04960), thymidylate synthetase L homeolog (tyms.L), thymidylate synthase (XBJ1_RS15770), thymidylate synthase (EAMY_RS20680), thymidylate synthase (Tyms), thymidylate synthetase (Tyms), ECK2823, FN1, HST422, JW2795, TMS, ts, Ts, TS

Bezeichner auf Proteinebene für TYMS

  • fibronectin 1
  • thymidylate synthase
  • thymidylate synthetase
  • thymidylate synthase-like
  • Tsase
  • TSase
  • TS
Sie sind hier:
Kundenservice