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Ubiquilin 2 Produkte

(Ubiquilin 2 (UBQLN2))
This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases\; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein. [provided by RefSeq, Oct 2009].

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Ausgewählte Ubiquilin 2 Kategorien

Ubiquilin 2 Antikörper

High quality antibodies with extensive validation data.

Ubiquilin 2 ELISA Kits

Reliable ELISA kits for a wide range of species.

Ubiquilin 2 Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene Ubiquilin 2 Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation WB, ELISA, IF
Validierungen
  • (11)
  • (7)
Kat. Nr. ABIN565449
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, IHC, IF
Validierungen
  • (5)
Kat. Nr. ABIN6149859
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation ELISA, IHC, IF
Validierungen
  • (3)
Kat. Nr. ABIN7174228
Menge 100 μg
Datenblatt Datenblatt

Empfohlene Ubiquilin 2 ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6971032
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6960336
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Quantitative Competition ELISA
Validierungen
Kat. Nr. ABIN5591997
Menge 96 tests
Datenblatt Datenblatt

Empfohlene Ubiquilin 2 Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1324460
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1324462
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Escherichia coli (E. coli)
Validierungen
  • (1)
Kat. Nr. ABIN7125571
Menge 50 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren Ubiquilin 2 Produkten

Alexander, Ghanbari Niaki, Zhang, Sarkar, Liu, Nirujogi, Pandey, Myong, Wang: "Ubiquilin 2 modulates ALS/FTD-linked FUS-RNA complex dynamics and stress granule formation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, Issue 49, pp. E11485-E11494, (2019) (PubMed).

Sharkey, Safren, Pithadia, Gerson, Dulchavsky, Fischer, Patel, Lantis, Ashraf, Kim, Meliki, Minakawa, Barmada, Ivanova, Paulson: "Mutant UBQLN2 promotes toxicity by modulating intrinsic self-assembly." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, Issue 44, pp. E10495-E10504, (2018) (PubMed).

Yau, Doerner, Castellanos, Haakonsen, Werner, Wang, Yang, Martinez-Martin, Matsumoto, Dixit, Rape: "Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality Control." in: Cell, Vol. 171, Issue 4, pp. 918-933.e20, (2017) (PubMed).

Hjerpe, Bett, Keuss, Solovyova, McWilliams, Johnson, Sahu, Varghese, Wood, Wightman, Osborne, Bates, Glickman, Trost, Knebel, Marchesi, Kurz: "UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome." in: Cell, Vol. 166, Issue 4, pp. 935-49, (2016) (PubMed).

Le, Chang, Kovlyagina, Georgiou, Safren, Braunstein, Kvarta, Van Dyke, LeGates, Philips, Morrison, Thompson, Puche, Gould, Rothstein, Wong, Monteiro: "Motor neuron disease, TDP-43 pathology, and memory deficits in mice expressing ALS-FTD-linked UBQLN2 mutations." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, Issue 47, pp. E7580-E7589, (2016) (PubMed).

Riku, Watanabe, Yoshida, Mimuro, Iwasaki, Masuda, Ishigaki, Katsuno, Sobue: "Marked Involvement of the Striatal Efferent System in TAR DNA-Binding Protein 43 kDa-Related Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis." in: Journal of neuropathology and experimental neurology, (2016) (PubMed).

Porta, Kwong, Trojanowski, Lee: "Drosha inclusions are new components of dipeptide-repeat protein aggregates in FTLD-TDP and ALS C9orf72 expansion cases." in: Journal of neuropathology and experimental neurology, Vol. 74, Issue 4, pp. 380-7, (2015) (PubMed).

Zeng, Wang, Merillat, N Minakawa, Perkins, Ramani, Tallaksen-Greene, Costa, Albin, Paulson: "Differential recruitment of UBQLN2 to nuclear inclusions in the polyglutamine diseases HD and SCA3." in: Neurobiology of disease, Vol. 82, pp. 281-8, (2015) (PubMed).

Ceballos-Diaz, Rosario, Park, Chakrabarty, Sacino, Cruz, Siemienski, Lara, Moran, Ravelo, Golde, McFarland: "Viral expression of ALS-linked ubiquilin-2 mutants causes inclusion pathology and behavioral deficits in mice." in: Molecular neurodegeneration, Vol. 10, pp. 25, (2015) (PubMed).

Satoh, Tabunoki, Ishida, Saito, Arima: "Ubiquilin-1 immunoreactivity is concentrated on Hirano bodies and dystrophic neurites in Alzheimer's disease brains." in: Neuropathology and applied neurobiology, Vol. 39, Issue 7, pp. 817-30, (2014) (PubMed).

Synonyme und alternative Namen zu Ubiquilin 2

ubiquilin 2 (UBQLN2), ubiquilin 2 (Ubqln2), ALS15, CHAP1, Chap1, DSK2, Dsk2, HRIHFB2157, N4BP4, Plic-2, PLIC2, Plic2, RGD1563566, UBQLN2

Bezeichner auf Proteinebene für Ubiquilin 2

  • Nedd4 binding protein 4
  • protein linking IAP with cytoskeleton 2
  • ubiquilin-2
  • ubiquitin-like product Chap1/Dsk2
  • Ubiquitin-related protein
  • ubiquilin 2
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