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UIMC1 Produkte

(Ubiquitin Interaction Motif Containing 1 (UIMC1))

Kategorien

Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B\; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly Act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1 (By similarity).

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Ausgewählte UIMC1 Kategorien

UIMC1 Antikörper

High quality antibodies with extensive validation data.

UIMC1 ELISA Kits

Reliable ELISA kits for a wide range of species.

UIMC1 Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene UIMC1 Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation WB, FACS
Validierungen
  • (1)
  • (2)
Kat. Nr. ABIN1944736
Menge 400 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, ELISA, IHC
Validierungen
  • (2)
Kat. Nr. ABIN7145750
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, IP
Validierungen
  • (2)
Kat. Nr. ABIN526885
Menge 100 μL
Datenblatt Datenblatt

Empfohlene UIMC1 ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method
Validierungen
Kat. Nr. ABIN1124110
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Mouse
Analytical Method
Validierungen
Kat. Nr. ABIN1124111
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Rat
Analytical Method
Validierungen
Kat. Nr. ABIN1124113
Menge 96 tests
Datenblatt Datenblatt

Empfohlene UIMC1 Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1324614
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr. ABIN3096257
Menge 1 mg
Datenblatt Datenblatt
Reaktivität Rat
Source Yeast
Validierungen
Kat. Nr. ABIN1634738
Menge 1 mg
Datenblatt Datenblatt

Neueste Publikationen zu unseren UIMC1 Produkten

Baranes-Bachar, Levy-Barda, Oehler, Reid, Soria-Bretones, Voss, Chung, Park, Liu, Yoon, Li, Dellaire, Misteli, Huertas, Rothenberg, Ramadan, Ziv, Shiloh: "The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair." in: Molecular cell, Vol. 69, Issue 5, pp. 866-878.e7, (2019) (PubMed).

Bodo, Campagne, Thin, Higginson, Vargas, Hua, Fuller, Ackerstaff, Russell, Zhang, Klingler, Cho, Kaag, Mazaheri, Rimner, Manova-Todorova, Epel, Zatcky, Cleary, Rao, Yamada, Zelefsky, Halpern et al.: "Single-dose radiotherapy disables tumor cell homologous recombination via ischemia/reperfusion injury. ..." in: The Journal of clinical investigation, Vol. 129, Issue 2, pp. 786-801, (2019) (PubMed).

Watanabe, Iimori, Chan, Hara, Kitao, Maehara: "MDC1 methylation mediated by lysine methyltransferases EHMT1 and EHMT2 regulates active ATM accumulation flanking DNA damage sites." in: Scientific reports, Vol. 8, Issue 1, pp. 10888, (2018) (PubMed).

Yasuhara, Kato, Hagiwara, Shiotani, Yamauchi, Nakada, Shibata, Miyagawa: "Human Rad52 Promotes XPG-Mediated R-loop Processing to Initiate Transcription-Associated Homologous Recombination Repair." in: Cell, Vol. 175, Issue 2, pp. 558-570.e11, (2018) (PubMed).

Ha, Ma, Lin, Tang, Lian, Zhao, Li, Zhen, Pei, Han, Malumbres, Jin, Chen, Zhao, Zhu, Zhang: "The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites." in: Nature communications, Vol. 8, pp. 15751, (2017) (PubMed).

Renaud, Barascu, Rosselli: "Impaired TIP60-mediated H4K16 acetylation accounts for the aberrant chromatin accumulation of 53BP1 and RAP80 in Fanconi anemia pathway-deficient cells." in: Nucleic acids research, Vol. 44, Issue 2, pp. 648-56, (2016) (PubMed).

Lin, Ratner, Whicker, Lee, Sartorelli: "Triapine disrupts CtIP-mediated homologous recombination repair and sensitizes ovarian cancer cells to PARP and topoisomerase inhibitors." in: Molecular cancer research : MCR, Vol. 12, Issue 3, pp. 381-93, (2014) (PubMed).

Kato, Nakajima, Ui, Muto-Terao, Ogiwara, Nakada: "Fine-tuning of DNA damage-dependent ubiquitination by OTUB2 supports the DNA repair pathway choice." in: Molecular cell, Vol. 53, Issue 4, pp. 617-30, (2014) (PubMed).

Hu, Paul, Wang: "Rap80 protein recruitment to DNA double-strand breaks requires binding to both small ubiquitin-like modifier (SUMO) and ubiquitin conjugates." in: The Journal of biological chemistry, Vol. 287, Issue 30, pp. 25510-9, (2012) (PubMed).

Hu, Kim, Castillo, Huang, Liu, Wang: "NBA1/MERIT40 and BRE interaction is required for the integrity of two distinct deubiquitinating enzyme BRCC36-containing complexes." in: The Journal of biological chemistry, Vol. 286, Issue 13, pp. 11734-45, (2011) (PubMed).

Synonyme und alternative Namen zu UIMC1

ubiquitin interaction motif containing 1 (UIMC1), ubiquitin interaction motif containing 1 (Uimc1), 9430016E08Rik, D330018D10Rik, D630032M02Rik, RAP80, RGD1307009, RIP110, Rxrip110, UIMC1, X2HRIP110

Bezeichner auf Proteinebene für UIMC1

  • ubiquitin interaction motif containing 1
  • BRCA1-A complex subunit RAP80-like
  • BRCA1-A complex subunit RAP80
  • receptor-associated protein 80
  • ubiquitin interaction motif-containing protein 1
  • receptor associated protein 80
  • retinoid X receptor-interacting protein 110
  • retinoid x receptor interacting protein
  • retinoid X receptor interacting protein 110
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