UPF3B Produkte
(UPF3 Regulator of Nonsense Transcripts Homolog B (UPF3B))
Kategorien
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Ausgewählte UPF3B Kategorien
UPF3B Antikörper
High quality antibodies with extensive validation data.
UPF3B Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene UPF3B Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, IHC (p)
Validierungen
- (1)
- (4)
Kat. Nr.
ABIN3043956
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
ELISA, IHC, IF
Validierungen
- (3)
Kat. Nr.
ABIN7167644
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Cow, Human
Applikation
WB, IHC, IHC (p)
Validierungen
- (2)
Kat. Nr.
ABIN203166
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene UPF3B ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6234778
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene UPF3B Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
HEK-293 Cells
Validierungen
- (1)
Kat. Nr.
ABIN2735037
Menge
20 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren UPF3B Produkten
: "Antisense suppression of the nonsense mediated decay factor Upf3b as a potential treatment for diseases caused by nonsense mutations." in: Genome biology, Vol. 19, Issue 1, pp. 4, (2018) (PubMed).: "RNA sequencing of synaptic and cytoplasmic Upf1-bound transcripts supports contribution of nonsense-mediated decay to epileptogenesis." in: Scientific reports, Vol. 7, pp. 41517, (2017) (PubMed).
Synonyme und alternative Namen zu UPF3B
UPF3B, regulator of nonsense mediated mRNA decay (UPF3B), UPF3 regulator of nonsense transcripts homolog B (yeast) (Upf3b), UPF3B, regulator of nonsense mediated mRNA decay (Upf3b), 5730594O13Rik, AI317193, AW541158, HUPF3B, MRXS14, RENT3B, RGD1560264, UPF3XBezeichner auf Proteinebene für UPF3B
- hUpf3p-X
- nonsense mRNA reducing factor 3B
- regulator of nonsense transcripts 3B
- up-frameshift suppressor 3 homolog B
- up-frameshift suppressor 3 homolog on chromosome X
- hUPF3B
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