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USP13 Produkte

(Ubiquitin Specific Peptidase 13 (Isopeptidase T-3) (USP13))

Kategorien

Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum- associated degradation (ERAD). Component of a regulatory loop that of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34- containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Mediates stabilization of SIAH2 independently of impairing SIAH2 autoubiquitination. Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked polyubiquitin chains. In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly. Able to cleave ISG15 in vitro\; however, additional experiments are required to confirm such data (By similarity).

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Ausgewählte USP13 Kategorien

USP13 Antikörper

High quality antibodies with extensive validation data.

USP13 Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene USP13 Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human, Mouse, Rat
Applikation WB, IHC, ELISA
Validierungen
  • (3)
Kat. Nr. ABIN6258346
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, IHC, ELISA
Validierungen
  • (2)
Kat. Nr. ABIN7184323
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human, Mouse
Applikation WB, IHC (p)
Validierungen
  • (2)
Kat. Nr. ABIN388901
Menge 400 μL
Datenblatt Datenblatt

Empfohlene USP13 ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
Kat. Nr. ABIN6222171
Menge 96 tests
Datenblatt Datenblatt

Empfohlene USP13 Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1324750
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr. ABIN3096193
Menge 1 mg
Datenblatt Datenblatt
Reaktivität Human
Source HEK-293 Cells
Validierungen
  • (1)
Kat. Nr. ABIN2712394
Menge 20 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren USP13 Produkten

Cheung, Yang, Lee, Rennert, Chan: "Hypermethylation of genes in testicular embryonal carcinomas." in: British journal of cancer, Vol. 114, Issue 2, pp. 230-6, (2016) (PubMed).

Kato, Nicholson, Neiman, Rantalainen, Holmes, Barrett, Uhlén, Nilsson, Spector, Schwenk: "Variance decomposition of protein profiles from antibody arrays using a longitudinal twin model." in: Proteome science, Vol. 9, pp. 73, (2011) (PubMed).

Puente, Sánchez, Overall, López-Otín: "Human and mouse proteases: a comparative genomic approach." in: Nature reviews. Genetics, Vol. 4, Issue 7, pp. 544-58, (2003) (PubMed).

Synonyme und alternative Namen zu USP13

ubiquitin specific peptidase 13 (USP13), ubiquitin specific peptidase 13 (isopeptidase T-3) (Usp13), ubiquitin specific peptidase 13 (isopeptidase T-3) (USP13), ubiquitin specific peptidase 13 (usp13), ubiquitin specific peptidase 13 (isopeptidase T-3) (usp13), ubiquitin carboxyl-terminal hydrolase 13 (MGYG_01656), universal stress protein (RR_RS02895), 2700071E21Rik, AI848077, IsoT-3, ISOT3, MGC163140, usp13

Bezeichner auf Proteinebene für USP13

  • deubiquitinating enzyme 13
  • isopeptidase T-3
  • ubiquitin carboxyl-terminal hydrolase 13
  • ubiquitin specific protease 13 (isopeptidase T-3)
  • ubiquitin thioesterase 13
  • ubiquitin thiolesterase 13
  • ubiquitin-specific-processing protease 13
  • ubiquitin specific peptidase 13 (isopeptidase T-3)
  • ubiquitin carboxyl-terminal hydrolase 13-like
  • ubiquitin thiolesterase 13-like
  • Deubiquitinating enzyme 13
  • Ubiquitin thioesterase 13
  • Ubiquitin-specific-processing protease 13
  • ubiquitin specific peptidase 13
  • universal stress protein
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