USP2 Produkte
(Ubiquitin Specific Peptidase 2 (USP2))
Kategorien
This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011].
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Ausgewählte USP2 Kategorien
USP2 Antikörper
High quality antibodies with extensive validation data.
USP2 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene USP2 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IHC (p)
Validierungen
- (12)
- (4)
Kat. Nr.
ABIN388879
Menge
400 μL
Datenblatt
Datenblatt
Reaktivität
Human, Rat
Applikation
WB, IHC (p)
Validierungen
- (4)
- (4)
Kat. Nr.
ABIN388877
Menge
400 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
ELISA, IHC
Validierungen
- (2)
Kat. Nr.
ABIN7174279
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene USP2 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6232795
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene USP2 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7420525
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7420528
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr.
ABIN3096154
Menge
1 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren USP2 Produkten
: "Ubiquitin-Specific Protease 2 Modulates the Lipopolysaccharide-Elicited Expression of Proinflammatory Cytokines in Macrophage-like HL-60 Cells." in: Mediators of inflammation, Vol. 2017, pp. 6909415, (2018) (PubMed).: "Deubiquitinase USP2a Sustains Interferons Antiviral Activity by Restricting Ubiquitination of Activated STAT1 in the Nucleus." in: PLoS pathogens, Vol. 12, Issue 7, pp. e1005764, (2017) (PubMed).
: "Small Molecule Inhibition of the Ubiquitin-specific Protease USP2 Accelerates cyclin D1 Degradation and Leads to Cell Cycle Arrest in Colorectal Cancer and Mantle Cell Lymphoma Models." in: The Journal of biological chemistry, Vol. 291, Issue 47, pp. 24628-24640, (2017) (PubMed).
: "Overexpression of ubiquitin-specific protease 2a (USP2a) and nuclear factor erythroid 2-related factor 2 (Nrf2) in human gliomas." in: Journal of the neurological sciences, Vol. 363, pp. 249-52, (2016) (PubMed).
: "Ubiquitin-specific protease 2b negatively regulates IFN-? production and antiviral activity by targeting TANK-binding kinase 1." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 193, Issue 5, pp. 2230-7, (2014) (PubMed).
: "Ubiquitin-specific protease 2-69 in macrophages potentially modulates metainflammation." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 27, Issue 12, pp. 4940-53, (2013) (PubMed).
: "USP2a protein deubiquitinates and stabilizes the circadian protein CRY1 in response to inflammatory signals." in: The Journal of biological chemistry, Vol. 287, Issue 30, pp. 25280-91, (2012) (PubMed).
: "Ubiquitination-deubiquitination balance dictates ligand-stimulated PTHR sorting." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 26, Issue 12, pp. 2923-34, (2011) (PubMed).
: "Mice lacking the USP2 deubiquitinating enzyme have severe male subfertility associated with defects in fertilization and sperm motility." in: Biology of reproduction, Vol. 85, Issue 3, pp. 594-604, (2011) (PubMed).
: "Ubiquitin-specific protease 2-45 (Usp2-45) binds to epithelial Na+ channel (ENaC)-ubiquitylating enzyme Nedd4-2." in: American journal of physiology. Renal physiology, Vol. 301, Issue 1, pp. F189-96, (2011) (PubMed).
Synonyme und alternative Namen zu USP2
ubiquitin specific peptidase 2 (USP2), ubiquitin specific peptidase 2 (Usp2), ubiquitin specific peptidase 2a (usp2a), B930035K21Rik, UBP-t, UBP41, Ubp41, UBP46, ubp52, ubp66, USP9, zgc:92134Bezeichner auf Proteinebene für USP2
- 41 kDa ubiquitin-specific protease
- deubiquitinating enzyme 2
- ubiquitin carboxyl-terminal hydrolase 2
- ubiquitin specific protease 12
- ubiquitin specific protease 9
- ubiquitin thioesterase 2
- ubiquitin-specific-processing protease 2
- ubiquitin specific protease 2
- ubiquitin thiolesterase 2
- ubiquitin-specific-processing protease testis
- family of cysteine protease
- ubiquitin specific protease 41
- ubiquitin specific protease 46
- ubiquitin specific protease 52
- ubiquitin specific protease 66
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