VAV1 Produkte
(Vav 1 Oncogene (VAV1))
Kategorien
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012].
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Ausgewählte VAV1 Kategorien
VAV1 Antikörper
High quality antibodies with extensive validation data.
VAV1 ELISA Kits
Reliable ELISA kits for a wide range of species.
VAV1 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene VAV1 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, FACS
Validierungen
- (2)
- (5)
Kat. Nr.
ABIN969581
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Mouse
Applikation
WB, IHC, IP, ICC
Validierungen
- (5)
Kat. Nr.
ABIN7444313
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, ELISA, IHC, IF, ICC
Validierungen
- (1)
- (4)
Kat. Nr.
ABIN6256653
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene VAV1 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validierungen
Kat. Nr.
ABIN1380145
Menge
2 x 96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Sandwich ELISA
Validierungen
Kat. Nr.
ABIN417930
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene VAV1 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7125706
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1324929
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
HEK-293 Cells
Validierungen
- (1)
- (1)
Kat. Nr.
ABIN2735197
Menge
20 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren VAV1 Produkten
: "Transcriptomic Analysis of the Mechanisms for Alleviating Psoriatic Dermatitis Using Taodan Granules in an Imiquimod-Induced Psoriasis-like Mouse Model." in: Frontiers in pharmacology, Vol. 12, pp. 632414, (2021) (PubMed).: "Identification of the catalytic site of phospholipase D2 (PLD2) newly described guanine nucleotide exchange factor activity." in: The Journal of biological chemistry, Vol. 287, Issue 49, pp. 41417-31, (2012) (PubMed).
: "Vav1 is a crucial molecule in monocytic/macrophagic differentiation of myeloid leukemia-derived cells." in: Cell and tissue research, Vol. 345, Issue 1, pp. 163-75, (2011) (PubMed).
: "The distinct role of guanine nucleotide exchange factor Vav1 in Bcl-2 transcription and apoptosis inhibition in Jurkat leukemia T cells." in: Acta pharmacologica Sinica, Vol. 32, Issue 1, pp. 99-107, (2011) (PubMed).
: "Phospholipase D2 (PLD2) is a guanine nucleotide exchange factor (GEF) for the GTPase Rac2." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 49, pp. 19617-22, (2011) (PubMed).
: "Signal-transducing adaptor protein-2 regulates stromal cell-derived factor-1 alpha-induced chemotaxis in T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 12, pp. 7966-74, (2009) (PubMed).
: "Acidic region tyrosines provide access points for allosteric activation of the autoinhibited Vav1 Dbl homology domain." in: Biochemistry, Vol. 44, Issue 46, pp. 15257-68, (2005) (PubMed).
: "Membrane localization and function of Vav3 in T cells depend on its association with the adapter SLP-76." in: The Journal of biological chemistry, Vol. 280, Issue 15, pp. 15289-99, (2005) (PubMed).
: "Cbl-mediated ubiquitinylation and negative regulation of Vav." in: The Journal of biological chemistry, Vol. 278, Issue 40, pp. 38495-504, (2003) (PubMed).
: "A guanine nucleotide exchange factor-independent function of Vav1 in transcriptional activation." in: The Journal of biological chemistry, Vol. 275, Issue 3, pp. 2185-90, (2000) (PubMed).
Synonyme und alternative Namen zu VAV1
vav guanine nucleotide exchange factor 1 (VAV1), vav guanine nucleotide exchange factor 1 (Vav1), vav 1 oncogene (Vav1), vav guanine nucleotide exchange factor 1 L homeolog (vav1.L), VAV, Vav, vav-TBezeichner auf Proteinebene für VAV1
- vav 1 oncogene
- proto-oncogene vav
- p95
- p95vav
- vav oncogene
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