VHL Produkte
(Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL))
Kategorien
Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
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Ausgewählte VHL Kategorien
VHL Antikörper
High quality antibodies with extensive validation data.
VHL ELISA Kits
Reliable ELISA kits for a wide range of species.
VHL Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene VHL Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IF, IHC (p), IP, ICC
Validierungen
- (1)
- (8)
Kat. Nr.
ABIN2854928
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, IF
Validierungen
- (3)
- (6)
Kat. Nr.
ABIN3020968
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse
Applikation
WB, FACS, IF, IHC (p)
Validierungen
- (7)
Kat. Nr.
ABIN390462
Menge
200 μL
Datenblatt
Datenblatt
Empfohlene VHL ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6971170
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Rat
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6960511
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN5518585
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene VHL Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
- (1)
Kat. Nr.
ABIN1325000
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN2132533
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7424887
Menge
100 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren VHL Produkten
: "Protective effect of salidroside against bone loss via hypoxia-inducible factor-1α pathway-induced angiogenesis." in: Scientific reports, Vol. 6, pp. 32131, (2018) (PubMed).: "VHL deficiency augments anthracycline sensitivity of clear cell renal cell carcinomas by down-regulating ALDH2." in: Nature communications, Vol. 8, pp. 15337, (2018) (PubMed).
: "Salidroside accelerates fracture healing through cell-autonomous and non-autonomous effects on osteoblasts." in: Cell and tissue research, Vol. 367, Issue 2, pp. 197-211, (2017) (PubMed).
: "Forkhead Transcription Factor 3a (FOXO3a) Modulates Hypoxia Signaling via Up-regulation of the von Hippel-Lindau Gene (VHL)." in: The Journal of biological chemistry, Vol. 291, Issue 49, pp. 25692-25705, (2017) (PubMed).
: "An ID2-dependent mechanism for VHL inactivation in cancer." in: Nature, Vol. 529, Issue 7585, pp. 172-7, (2016) (PubMed).
: "WSB1 promotes tumor metastasis by inducing pVHL degradation." in: Genes & development, Vol. 29, Issue 21, pp. 2244-57, (2015) (PubMed).
: "Jumonji Domain Containing Protein 6: A Novel Oxygen Sensor in the Human Placenta." in: Endocrinology, Vol. 156, Issue 8, pp. 3012-25, (2015) (PubMed).
: "HIF-1α disturbs osteoblasts and osteoclasts coupling in bone remodeling by up-regulating OPG expression." in: In vitro cellular & developmental biology. Animal, Vol. 51, Issue 8, pp. 808-14, (2015) (PubMed).
: "Oncotropic H-1 parvovirus infection degrades HIF-1α protein in human pancreatic cancer cells independently of VHL and RACK1." in: International journal of oncology, Vol. 46, Issue 5, pp. 2076-82, (2015) (PubMed).
: "pVHL Negatively Regulates Antiviral Signaling by Targeting MAVS for Proteasomal Degradation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 195, Issue 4, pp. 1782-90, (2015) (PubMed).
Synonyme und alternative Namen zu VHL
von Hippel-Lindau tumor suppressor (VHL), von Hippel-Lindau (Vhl), von Hippel-Lindau tumor suppressor (vhl), von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase (VHL), von Hippel-Lindau disease tumor suppressor (CpipJ_CPIJ009992), von Hippel-Lindau tumor suppressor (Vhl), BcDNA:RH61560, CG13221, d-VHL, d-vhl, Dmel\\CG13221, dmVHL, DVhl, Dvhl, dVHL, HRCA1, hrca1, pVHL, RCA1, rca1, VHL, vhl, VHL1, vhl1, Vhlh, zgc:158722Bezeichner auf Proteinebene für VHL
- elongin binding protein
- protein G7
- von Hippel-Lindau disease tumor suppressor
- CG13221-PA
- CG13221-PB
- Vhl-PA
- Vhl-PB
- von hippel lindau
- von hippel lindau protein
- pVHL
- von Hippel-Lindau tumor suppressor
- von Hippel-Lindau syndrome homolog
- von Hippel-Lindau syndrome protein homolog
- Von Hippel-Lindau disease tumor suppressor
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