VRK1 Produkte
(Vaccinia Related Kinase 1 (VRK1))
Kategorien
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. [provided by RefSeq, Jul 2008].
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Ausgewählte VRK1 Kategorien
VRK1 Antikörper
High quality antibodies with extensive validation data.
VRK1 ELISA Kits
Reliable ELISA kits for a wide range of species.
VRK1 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene VRK1 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IP, IF, RNAi
Validierungen
- (6)
Kat. Nr.
ABIN521352
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC, IP, IF
Validierungen
- (11)
Kat. Nr.
ABIN2452161
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC
Validierungen
- (3)
Kat. Nr.
ABIN7169217
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene VRK1 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6960427
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6730302
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Validierungen
Kat. Nr.
ABIN1157429
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene VRK1 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1325111
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1325109
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Insect Cells
Validierungen
Kat. Nr.
ABIN5509194
Menge
10 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren VRK1 Produkten
: "VRK1 regulates Cajal body dynamics and protects coilin from proteasomal degradation in cell cycle." in: Scientific reports, Vol. 5, pp. 10543, (2015) (PubMed).: "Depletion of the protein kinase VRK1 disrupts nuclear envelope morphology and leads to BAF retention on mitotic chromosomes." in: Molecular biology of the cell, Vol. 25, Issue 6, pp. 891-903, (2014) (PubMed).
: "Vaccinia-related kinase 1 (VRK1) confers resistance to DNA-damaging agents in human breast cancer by affecting DNA damage response." in: Oncotarget, Vol. 5, Issue 7, pp. 1770-8, (2014) (PubMed).
: "Molecular genetic analysis of VRK1 in mammary epithelial cells: depletion slows proliferation in vitro and tumor growth and metastasis in vivo." in: Oncogenesis, Vol. 2, pp. e48, (2013) (PubMed).
: "Rewiring of human lung cell lineage and mitotic networks in lung adenocarcinomas." in: Nature communications, Vol. 4, pp. 1701, (2013) (PubMed).
: "Vaccinia-related kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damage." in: The Journal of biological chemistry, Vol. 287, Issue 28, pp. 23757-68, (2012) (PubMed).
: "The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines." in: The FEBS journal, Vol. 273, Issue 11, pp. 2487-504, (2006) (PubMed).
: "Characterization of three paralogous members of the Mammalian vaccinia related kinase family." in: The Journal of biological chemistry, Vol. 279, Issue 9, pp. 7934-46, (2004) (PubMed).
: "Kinetic properties of p53 phosphorylation by the human vaccinia-related kinase 1." in: Archives of biochemistry and biophysics, Vol. 399, Issue 1, pp. 1-5, (2002) (PubMed).
: "The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein." in: Oncogene, Vol. 19, Issue 32, pp. 3656-64, (2000) (PubMed).
Synonyme und alternative Namen zu VRK1
vaccinia related kinase 1 L homeolog (vrk1.L), vaccinia related kinase 1 (vrk1), vaccinia related kinase 1 (VRK1), Serine/threonine-protein kinase VRK1 (vrk-1), vaccinia related kinase 1 (Vrk1), 51PK, MGC64390, MGC75762, PCH1, PCH1A, vrk1, VRK1, wu:fe16f06, zgc:56266Bezeichner auf Proteinebene für VRK1
- vaccinia related kinase 1
- serine/threonine-protein kinase VRK1
- serine/threonine-protein kinase VRK1-like
- vaccinia virus B1R-related kinase 1
- vaccinia-related kinase 1
- serine/threonine-protein kinase 51PK
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