WISP1 Produkte
(WNT1 Inducible Signaling Pathway Protein 1 (WISP1))
Kategorien
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2011].
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Ausgewählte WISP1 Kategorien
WISP1 Antikörper
High quality antibodies with extensive validation data.
WISP1 ELISA Kits
Reliable ELISA kits for a wide range of species.
WISP1 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene WISP1 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IF, FACS
Validierungen
- (7)
Kat. Nr.
ABIN238610
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Mouse
Applikation
WB, IHC, IP, ICC
Validierungen
- (5)
Kat. Nr.
ABIN7436372
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, ELISA, IF
Validierungen
- (4)
Kat. Nr.
ABIN7175846
Menge
100 μg
Datenblatt
Datenblatt
Empfohlene WISP1 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
- (1)
Kat. Nr.
ABIN6962685
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6960559
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6960558
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene WISP1 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Mouse
Source
HEK-293 Cells
Validierungen
- (2)
Kat. Nr.
ABIN7275850
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1325341
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN935909
Menge
20 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren WISP1 Produkten
: "Tao-Hong-Si-Wu Decoction promotes angiogenesis after cerebral ischaemia in rats via platelet microparticles." in: Chinese journal of natural medicines, Vol. 18, Issue 8, pp. 620-627, (2020) (PubMed).: "Based on HIF-1α/Wnt/β-Catenin Pathway to Explore the Effect of Qingshen Granules on Chronic Renal Failure Patients: A Randomized Controlled Trial." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2019, pp. 7656105, (2019) (PubMed).
: "Resveratrol Attenuates Hyperoxia-induced Oxidative Stress, Inflammation and Fibrosis and Suppresses Wnt/?-catenin Signaling in Lungs of Neonatal Rats." in: Clinical and experimental pharmacology & physiology, (2015) (PubMed).
: "WISP-2 in human gastric cancer and its potential metastatic suppressor role in gastric cancer cells mediated by JNK and PLC-? pathways." in: British journal of cancer, Vol. 113, Issue 6, pp. 921-33, (2015) (PubMed).
: "miR-92a regulates TGF-β1-induced WISP1 expression in pulmonary fibrosis." in: The international journal of biochemistry & cell biology, Vol. 53, pp. 432-41, (2014) (PubMed).
: "WISP1, a pro-mitogenic, pro-survival factor, mediates tumor necrosis factor-alpha (TNF-alpha)-stimulated cardiac fibroblast proliferation but inhibits TNF-alpha-induced cardiomyocyte death." in: The Journal of biological chemistry, Vol. 284, Issue 21, pp. 14414-27, (2009) (PubMed).
: "Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling." in: Science (New York, N.Y.), Vol. 316, Issue 5827, pp. 1043-6, (2007) (PubMed).
: "Overexpression of WISP-1 down-regulated motility and invasion of lung cancer cells through inhibition of Rac activation." in: The Journal of biological chemistry, Vol. 278, Issue 13, pp. 11465-70, (2003) (PubMed).
: "Human WISP1v, a member of the CCN family, is associated with invasive cholangiocarcinoma." in: Hepatology (Baltimore, Md.), Vol. 37, Issue 5, pp. 1122-9, (2003) (PubMed).
: "Regulation of the Wnt signaling pathway by disabled-2 (Dab2)." in: The EMBO journal, Vol. 22, Issue 12, pp. 3084-94, (2003) (PubMed).
Synonyme und alternative Namen zu WISP1
WNT1 inducible signaling pathway protein 1 (WISP1), WNT1 inducible signaling pathway protein 1a (wisp1a), WNT1 inducible signaling pathway protein 1 (Wisp1), WNT1-inducible-signaling pathway protein 1-like (LOC100627044), WNT1 inducible signaling pathway protein 1b (wisp1b), AW146261, CCN4, Elm1, si:ch211-38f10.2, WISP-1, WISP1, WISP1c, WISP1i, WISP1tc, zgc:172276Bezeichner auf Proteinebene für WISP1
- CCN family member 4
- WNT1 induced secreted protein 1
- WNT1-inducible-signaling pathway protein 1
- Wnt-1 inducible signaling pathway protein 1
- Wnt-1-induced secreted protein
- WNT1 inducible signaling pathway protein 1
- wisp1
- zWISP1-c19
- ELM-1
- WISP-1
- zWISP1-c16
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