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WRAP53 Produkte

(WD Repeat Containing, Antisense To TP53 (WRAP53))
This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011].

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Ausgewählte WRAP53 Kategorien

WRAP53 Antikörper

High quality antibodies with extensive validation data.

WRAP53 ELISA Kits

Reliable ELISA kits for a wide range of species.

WRAP53 Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene WRAP53 Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation WB, ELISA, IF
Validierungen
  • (1)
  • (4)
Kat. Nr. ABIN527367
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, IF
Validierungen
  • (1)
  • (3)
Kat. Nr. ABIN527366
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Applikation WB
Validierungen
  • (1)
  • (1)
Kat. Nr. ABIN527365
Menge 50 μg
Datenblatt Datenblatt

Empfohlene WRAP53 ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method
Validierungen
Kat. Nr. ABIN1161126
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Mouse
Analytical Method
Validierungen
Kat. Nr. ABIN1161127
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Rat
Analytical Method
Validierungen
Kat. Nr. ABIN1161128
Menge 96 tests
Datenblatt Datenblatt

Empfohlene WRAP53 Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1325280
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1325282
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr. ABIN3096370
Menge 1 mg
Datenblatt Datenblatt

Neueste Publikationen zu unseren WRAP53 Produkten

MacNeil, Lambert-Lanteigne, Autexier: "N-terminal residues of human dyskerin are required for interactions with telomerase RNA that prevent RNA degradation." in: Nucleic acids research, Vol. 47, Issue 10, pp. 5368-5380, (2019) (PubMed).

Yuan, Cao, Hu, Bao, Wang, Cao, Yuan, Lv, Hu: "Clinical, cellular, and bioinformatic analyses reveal involvement of WRAP53 overexpression in carcinogenesis of lung adenocarcinoma." in: Tumour biology, Vol. 39, Issue 3, pp. 1010428317694309, (2017) (PubMed).

Vogan, Zhang, Youmans, Regalado, Johnson, Hockemeyer, Collins: "Minimized human telomerase maintains telomeres and resolves endogenous roles of H/ACA proteins, TCAB1, and Cajal bodies." in: eLife, Vol. 5, (2016) (PubMed).

Vogan, Collins: "Dynamics of Human Telomerase Holoenzyme Assembly and Subunit Exchange across the Cell Cycle." in: The Journal of biological chemistry, Vol. 290, Issue 35, pp. 21320-35, (2015) (PubMed).

Schertzer, Jouravleva, Perderiset, Dingli, Loew, Le Guen, Bardoni, de Villartay, Revy, Londoño-Vallejo: "Human regulator of telomere elongation helicase 1 (RTEL1) is required for the nuclear and cytoplasmic trafficking of pre-U2 RNA." in: Nucleic acids research, Vol. 43, Issue 3, pp. 1834-47, (2015) (PubMed).

Hedström, Pederiva, Farnebo, Nodin, Jirström, Brennan, Farnebo: "Downregulation of the cancer susceptibility protein WRAP53β in epithelial ovarian cancer leads to defective DNA repair and poor clinical outcome." in: Cell death & disease, Vol. 6, pp. e1892, (2015) (PubMed).

Henriksson, Rassoolzadeh, Hedström, Coucoravas, Julner, Goldstein, Imreh, Zhivotovsky, Kastan, Helleday, Farnebo: "The scaffold protein WRAP53? orchestrates the ubiquitin response critical for DNA double-strand break repair." in: Genes & development, Vol. 28, Issue 24, pp. 2726-38, (2014) (PubMed).

Sun, Luo, Gou, Hu, Wang, Li, Xiang, Zhang, Kong, Zhang, Yang, Li, Xiao, Li, Chen: "TCAB1: a potential target for diagnosis and therapy of head and neck carcinomas." in: Molecular cancer, Vol. 13, pp. 180, (2014) (PubMed).

Stern, Zyner, Pickett, Cohen, Bryan: "Telomerase recruitment requires both TCAB1 and Cajal bodies independently." in: Molecular and cellular biology, Vol. 32, Issue 13, pp. 2384-95, (2012) (PubMed).

Mahmoudi, Henriksson, Farnebo, Roberg, Farnebo: "WRAP53 promotes cancer cell survival and is a potential target for cancer therapy." in: Cell death & disease, Vol. 2, pp. e114, (2011) (PubMed).

Synonyme und alternative Namen zu WRAP53

WD repeat containing antisense to TP53 (WRAP53), WD repeat containing, antisense to TP53 (Wrap53), WD repeat containing, antisense to Trp53 (Wrap53), BC021790, DKCB3, TCAB1, WDR79, Wdr79

Bezeichner auf Proteinebene für WRAP53

  • WD repeat-containing protein 79
  • WD40 protein Wrap53
  • WD40 repeat-containing protein encoding RNA antisense to p53
  • telomerase Cajal body protein 1
  • WD repeat domain 79
  • WD40 repeat-containing protein encoded by RNA antisense to p53
  • WD repeat containing, antisense to TP53
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