WWOX Produkte
(WW Domain Containing Oxidoreductase (WWOX))
Kategorien
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms. [provided by RefSeq, Jul 2008].
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Ausgewählte WWOX Kategorien
WWOX Antikörper
High quality antibodies with extensive validation data.
WWOX ELISA Kits
Reliable ELISA kits for a wide range of species.
WWOX Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene WWOX Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC, IF, IP
Validierungen
- (6)
Kat. Nr.
ABIN7175871
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human, Mouse
Applikation
WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro)
Validierungen
- (1)
- (3)
Kat. Nr.
ABIN670551
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, ELISA, IHC
Validierungen
- (5)
Kat. Nr.
ABIN5693294
Menge
100 μg
Datenblatt
Datenblatt
Empfohlene WWOX ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Mouse
Analytical Method
Qualitative Cell ELISA
Validierungen
Kat. Nr.
ABIN1380821
Menge
2 x 96 tests
Datenblatt
Datenblatt
Reaktivität
Chicken
Analytical Method
Validierungen
Kat. Nr.
ABIN1167525
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene WWOX Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1325403
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7278826
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN2132583
Menge
50 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren WWOX Produkten
: "PGBD5 promotes site-specific oncogenic mutations in human tumors. ..." in: Nature genetics, Vol. 49, Issue 7, pp. 1005-1014, (2017) (PubMed).: "The ectopic expression of BRCA1 is associated with genesis, progression, and prognosis of breast cancer in young patients." in: Diagnostic pathology, Vol. 7, pp. 181, (2013) (PubMed).
: "WWOX gene restoration prevents lung cancer growth in vitro and in vivo." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 43, pp. 15611-6, (2005) (PubMed).
: "Frequent downregulation and loss of WWOX gene expression in human hepatocellular carcinoma." in: British journal of cancer, Vol. 91, Issue 4, pp. 753-9, (2004) (PubMed).
: "JNK1 physically interacts with WW domain-containing oxidoreductase (WOX1) and inhibits WOX1-mediated apoptosis." in: The Journal of biological chemistry, Vol. 278, Issue 11, pp. 9195-202, (2003) (PubMed).
: "WWOX, the FRA16D gene, behaves as a suppressor of tumor growth." in: Cancer research, Vol. 61, Issue 22, pp. 8068-73, (2001) (PubMed).
: "WWOX: a candidate tumor suppressor gene involved in multiple tumor types." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 20, pp. 11417-22, (2001) (PubMed).
: "WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer." in: Cancer research, Vol. 60, Issue 8, pp. 2140-5, (2000) (PubMed).
: "Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells." in: Human molecular genetics, Vol. 9, Issue 11, pp. 1651-63, (2000) (PubMed).
Synonyme und alternative Namen zu WWOX
WW domain containing oxidoreductase (Wwox), WW domain-containing oxidoreductase (LOC411815), WW domain containing oxidoreductase (WWOX), WW domain-containing oxidoreductase (CpipJ_CPIJ004939), WW domain-containing oxidoreductase (MCYG_01584), WW domain-containing oxidoreductase (VDBG_05631), WW domain-containing oxidoreductase (VDBG_01326), WW domain-containing oxidoreductase (VDBG_06753), WW domain-containing oxidoreductase (Tsp_03967), WW domain-containing oxidoreductase (LOC100284583), WW domain containing oxidoreductase (wwox), WW domain-containing oxidoreductase (Wwox), 5330426P09Rik, 9030416C10Rik, anon-EST:Posey177, CG7221, D16S432E, Dmel\\CG7221, DmWWOX, FOR, FRA16D, GB11795, HHCMA56, PRO0128, SDR41C1, WOX1, WWOX, zgc:55975Bezeichner auf Proteinebene für WWOX
- CG7221-PA
- Wwox-PA
- WW domain-containing oxidoreductase
- retinol dehydrogenase 12
- WW domain containing oxidoreductase
- WW domain-containing protein WWOX
- fragile site FRA16D oxidoreductase
- short chain dehydrogenase/reductase family 41C, member 1
- WW-domain oxidoreductase
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