WWP1 Produkte
(WW Domain Containing E3 Ubiquitin Protein Ligase 1 (WWP1))
Kategorien
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1\; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF.
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Ausgewählte WWP1 Kategorien
WWP1 Antikörper
High quality antibodies with extensive validation data.
WWP1 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene WWP1 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IP, IF, IHC (p)
Validierungen
- (6)
- (6)
Kat. Nr.
ABIN564794
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human, Mouse
Applikation
WB, ELISA, IHC
Validierungen
- (2)
Kat. Nr.
ABIN7245725
Menge
200 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA
Validierungen
- (2)
Kat. Nr.
ABIN524448
Menge
100 μg
Datenblatt
Datenblatt
Empfohlene WWP1 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6208453
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene WWP1 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7125747
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1325405
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr.
ABIN3096355
Menge
1 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren WWP1 Produkten
: "β-dystroglycan is regulated by a balance between WWP1-mediated degradation and protection from WWP1 by dystrophin and utrophin." in: Biochimica et biophysica acta. Molecular basis of disease, Vol. 1864, Issue 6 Pt A, pp. 2199-2213, (2018) (PubMed).: "Cardiomyocyte-specific overexpression of the ubiquitin ligase Wwp1 contributes to reduction in Connexin 43 and arrhythmogenesis." in: Journal of molecular and cellular cardiology, Vol. 88, pp. 1-13, (2015) (PubMed).
: "MiR-21 suppresses endothelial progenitor cell proliferation by activating the TGFβ signaling pathway via downregulation of WWP1." in: International journal of clinical and experimental pathology, Vol. 8, Issue 1, pp. 414-22, (2015) (PubMed).
: "Knockdown of WWP1 inhibits growth and induces apoptosis in hepatoma carcinoma cells through the activation of caspase3 and p53." in: Biochemical and biophysical research communications, Vol. 448, Issue 3, pp. 248-54, (2014) (PubMed).
: "WWP2-WWP1 ubiquitin ligase complex coordinated by PPM1G maintains the balance between cellular p73 and ?Np73 levels." in: Molecular and cellular biology, Vol. 34, Issue 19, pp. 3754-64, (2014) (PubMed).
: "The ubiquitin E3 ligase WWP1 decreases CXCL12-mediated MDA231 breast cancer cell migration and bone metastasis." in: Bone, Vol. 50, Issue 4, pp. 813-23, (2012) (PubMed).
: "WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) delays cellular senescence by promoting p27(Kip1) degradation in human diploid fibroblasts." in: The Journal of biological chemistry, Vol. 286, Issue 38, pp. 33447-56, (2011) (PubMed).
: "The E3 ubiquitin ligase WWP1 regulates ?Np63-dependent transcription through Lys63 linkages." in: Biochemical and biophysical research communications, Vol. 402, Issue 2, pp. 425-30, (2010) (PubMed).
: "Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5." in: The Biochemical journal, Vol. 423, Issue 1, pp. 31-9, (2009) (PubMed).
Synonyme und alternative Namen zu WWP1
WW domain containing E3 ubiquitin protein ligase 1 (WWP1), WW domain containing E3 ubiquitin protein ligase 1 (Wwp1), WW domain containing E3 ubiquitin protein ligase 1 (wwp1), 8030445B08Rik, AIP5, aip5, hSDRP1, hsdrp1, SDRP1, Tiul1, tiul1, WWP1Bezeichner auf Proteinebene für WWP1
- NEDD4-like E3 ubiquitin-protein ligase WWP1
- Nedd-4-like ubiquitin-protein ligase
- TGIF-interacting ubiquitin ligase 1
- WW domain-containing protein 1
- atrophin-1 interacting protein 5
- atrophin-1-interacting protein 5
- WW domain containing E3 ubiquitin protein ligase 1
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