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ZAK Produkte

(Mitogen-Activated Protein Kinase Kinase Kinase MLT (ZAK))
This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].

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Ausgewählte ZAK Kategorien

ZAK Antikörper

High quality antibodies with extensive validation data.

ZAK ELISA Kits

Reliable ELISA kits for a wide range of species.

ZAK Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene ZAK Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation WB, ELISA, IF, IHC (p)
Validierungen
  • (3)
  • (5)
Kat. Nr. ABIN565679
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, IHC, IF
Validierungen
  • (4)
Kat. Nr. ABIN6150360
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, IHC (p)
Validierungen
  • (1)
  • (2)
Kat. Nr. ABIN392643
Menge 400 μL
Datenblatt Datenblatt

Empfohlene ZAK ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Mouse
Analytical Method
Validierungen
Kat. Nr. ABIN1142997
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Quantitative Competition ELISA
Validierungen
Kat. Nr. ABIN5595441
Menge 96 tests
Datenblatt Datenblatt

Empfohlene ZAK Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (2)
Kat. Nr. ABIN1325564
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1325566
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Insect Cells
Validierungen
Kat. Nr. ABIN5509200
Menge 10 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren ZAK Produkten

Pescatore, Esposito, Draber, Walczak, Ursini: "NEMO regulates a cell death switch in TNF signaling by inhibiting recruitment of RIPK3 to the cell death-inducing complex II." in: Cell death & disease, Vol. 7, Issue 8, pp. e2346, (2017) (PubMed).

Nyati, Chator, Schinske, Gregg, Ross, Rehemtulla: "A Requirement for ZAK Kinase Activity in Canonical TGF-β Signaling." in: Translational oncology, Vol. 9, Issue 6, pp. 473-481, (2016) (PubMed).

Liu, McCleland, Stawiski, Gnad, Mayba, Haverty, Durinck, Chen, Klijn, Jhunjhunwala, Lawrence, Liu, Wan, Chopra, Yaylaoglu, Yuan, Ha, Gilbert, Reeder, Pau, Stinson, Stern, Manning, Wu, Neve et al.: "Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer. ..." in: Nature communications, Vol. 5, pp. 3830, (2014) (PubMed).

Pérez López, Cariolato, Maric, Gillet, Abriel, Diviani: "A-kinase anchoring protein Lbc coordinates a p38 activating signaling complex controlling compensatory cardiac hypertrophy." in: Molecular and cellular biology, Vol. 33, Issue 15, pp. 2903-17, (2013) (PubMed).

Cariolato, Cavin, Diviani: "A-kinase anchoring protein (AKAP)-Lbc anchors a PKN-based signaling complex involved in ?1-adrenergic receptor-induced p38 activation." in: The Journal of biological chemistry, Vol. 286, Issue 10, pp. 7925-37, (2011) (PubMed).

Cantrell: "Phosphoinositide 3-kinase signalling pathways." in: Journal of cell science, Vol. 114, Issue Pt 8, pp. 1439-45, (2001) (PubMed).

Blume-Jensen, Hunter: "Oncogenic kinase signalling." in: Nature, Vol. 411, Issue 6835, pp. 355-65, (2001) (PubMed).

Jhiang: "The RET proto-oncogene in human cancers." in: Oncogene, Vol. 19, Issue 49, pp. 5590-7, (2000) (PubMed).

Synonyme und alternative Namen zu ZAK

mitogen-activated protein kinase kinase kinase 20 (Map3k20), mitogen-activated protein kinase kinase kinase 20 (MAP3K20), AV006891, AZK, B230120H23Rik, MLK7, mlklak, MLT, MLTK, MLTKalpha, MLTKbeta, MRK, pk, RGD1561394

Bezeichner auf Proteinebene für ZAK

  • mitogen-activated protein kinase kinase kinase MLT
  • HCCS-4
  • MLK-like mitogen-activated protein triple kinase
  • human cervical cancer suppressor gene 4 protein
  • mixed lineage kinase 7
  • mixed lineage kinase with a leucine zipper and a sterile alpha motif
  • mixed lineage kinase-related kinase MRK-beta
  • MLK-related kinase
  • MRK
  • leucine zipper- and sterile alpha motif kinase ZAK
  • mixed lineage kinase-related kinase
  • sterile alpha motif- and leucine zipper-containing kinase AZK
  • sterile-alpha motif and leucine zipper containing kinase AZK
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